At the same time, after revealing the new talking chimera that he created from Nina and Alexander, Tucker forces Alphonse and Winry to accompany him to the Fifth Laboratory, where they find Edward as he verbally realizes that the Philosopher's Stone is created from humans. Edward manages to escape being interrogated with help from Mustang's aide Lieutenant Riza Hawkeye, using what he could deduce from the notes to investigate the clandestine Fifth Laboratory.
Hughes later makes a horrific discovery from his investigation and ends up being killed by Lust's associate Envy, who assumes Mustang's form to frame the colonel for the murder. Though Marcoh was murdered by Cornello's benefactor Lust as he and Winry find him, Edward acquires the man's notes and asks Hughes to decipher them while unknowingly alienating Alphonse to keep him safe. Alphonse remains behind to be examined by Tucker, who causes Alphonse to question his existence, while Edward and Winry head to Marcoh's last known whereabouts. Tim Marcoh as he created a philosopher's stone prior to going into hiding. As the brothers become fast friends with the man's young daughter Nina and their dog Alexander, Tucker suggests Edward to find Dr. After reaching East City and spending the night at the home of Major Maes Hughes and his pregnant wife, the brothers are provided with lodging when Major General Hakuro introduces them to Shou Tucker, a bio-alchemy authority who obtained his State Alchemist credentials by creating a talking chimera. As Mustang arrives to personally handle the situation, Edward exposes Cornello while the stone is revealed to be a fake. Years later, Edward and Alphonse confront a cultist named Father Cornello, whom they believe is using a philosopher's stone to recruit the people of Liore. After becoming a State Alchemist with the title "Fullmetal Alchemist", accompanied by their childhood friend and Automail mechanic Winry Rockwell, Edward begins his quest with Alphonse to find the legendary philosopher's stone which could repair their bodies. Edward later receives an invitation by Colonel Roy Mustang to join the military so he can research a means of restoring Alphonse's body. Edward then sacrifices his right arm to save his brother's soul and bind it to a suit of armor via a blood seal, later replacing his missing limbs with "automail" prosthetics. When the brothers commit the taboo act of Human Transmutation to resurrect Trisha after she dies of illness, it backfires and they suffer the consequences via the Law of Equivalent Exchange: Edward loses his left leg, while Alphonse is dragged into the Gate of Truth. In the country of Amestris, Edward Elric and his younger brother Alphonse live in the rural town of Resembool with their mother Trisha while self-learning alchemy at a young age.
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